BAFF mediates splenic B cell response and antibody production in experimental Chagas disease

DA BERMEJO, MC AMEZCUA VESELY, CL. MONTES, MC MERINO, EV ACOSTA-RODRIGUEZ, Y A GRUPPI.

PUBLIC LIBRARY SCIENCE

Año: 2010 p. 679 - 679

font face="AdvP41461E" size="2"> Abstract Background: B cells and antibodies are involved not only in controlling the spread of blood circulating Trypanosoma cruzi, but also in the autoreactive manifestations observed in Chagas disease. Acute infection results in polyclonal B cell activation associated with hypergammaglobulinemia, delayed specific humoral immunity and high levels of non-parasite specific antibodies. Since TNF superfamily B lymphocyte Stimulator (BAFF) mediates polyclonal B cell response