Intracytoplasmic filamentous inclusions and IGHV rearrangements in a patient with chronic lymphocytic leukemia

RODRIGUEZ CECILIA M; STANGANELLI CARMEN; BUSSI CLAUDIO; ARROYO DANIELA S; SASTRE DARÍO; IRIBARREN PABLO; SLAVUTSKY IRMA

LEUKEMIA AND LYMPHOMA

TAYLOR & FRANCIS LTD

Año: 2017

1042-8194

hronic lymphocytic leukemia (CLL) represents the most common leukemia in theWestern world, accounting for ~30-40% of all adult leukemias. The disease is characterized by a highly variable clinical course, ranging from indolent cases to patients with aggressive and rapidly progressing disease. Although staging systems are reliable predictors of outcome, they do not fully explain the heterogeneity in treatment response and survival. In the last decades, several prognostic biomarkers have been identified, allowing the subdivision of this heterogeneous disease into clinical relevant subgroups. Among them, genomic alterations and the mutational status of the immunoglobulin heavy chain variable(IGHV) genes are of significance. Particularly, recurrent cytogenetic abnormalities namely deletions of chromosomes 11q, 13q, 17p and trisomy 12, define subgroups of patients with different clinical behavior and response to treatment while IGHV mutational status permit to distinguish two major CLL sub