`PHENOTYPIC AND FUNCTIONAL FEATURES OF MICROGLIA AND MONOCYTES AFTER SYSTEMIC LIPOPOLYSACCHARIDE CHALLENGE

JAVIER MARIA PERALTA RAMOS; EMILIA ANDREA GAVIGLIO; DANIELA SOLEDAD ARROYO; CLAUDIO BUSSI; PABLO IRIBARREN

Congreso; IV LASID Meeting; 2015

The ?immune privilege? of the central nervous system (CNS) is indispensable for damage limitation during inflammation. It is now clear that while peripheral immune components access to the CNS is restricted and tightly controlled, the CNS is capable of mounting dynamic immunologic and inflammatory responses to a variety of insults such as trauma, infections, toxins and systemic pro-inflammatory cytokines. Brain-resident microglia (Mi) and bloodderived monocytes, play essential roles in shaping the immune response in the CNS.These cells activate and migrate in response to chemokines produced during active immune responses and may contribute to the progression of neuroinflammation. In this study, we investigated the phenotypic and functional profile of tissue-resident microglia and recruited inflammatory monocytes (InfMo), to better understand the contribution of each population in the establishment and development of a neuroinflammatory process induced by systemic TLR4 stimulation.