`TISSUE-RESIDENT MICROGLIA AND RECRUITED MONOCYTES: RELEVANCE IN NEUROINFLAMMATION AFTER PERIPHERAL LIPOPOLYSACCHARIDE CHALLENGE ´.

PERALTA-RAMOS JAVIER M; GAVIGLIO EMILIA A; ARROYO DANIELA S; BUSSI CLAUDIO; IRIBARREN PABLO

Congreso; Keystone Symposia Microglia in the brain; 2016

The ?immune privilege? of the central nervous system (CNS) is indispensable for damage limitation during inflammation. It is now clearthat while peripheral immune components access to the CNS is restricted and tightly controlled, the CNS is capable of mountingdynamic immunologic and inflammatory responses to a variety of insults such as trauma, infections, toxins and systemic proinflammatorycytokines. Brain-resident microglia (Mi) and blood-derived monocytes, play essential roles in shaping the immune responsein the CNS.These cells activate and migrate in response to chemokines produced during active immune responses and may contribute to theprogression of neuroinflammation. In this study, we investigated the phenotypic and functional profile of tissue-resident microglia andrecruited inflammatory monocytes (InfMo), to better understand the contribution of each population in the establishment anddevelopment of a neuroinflammatory process induced by systemic TLR4 stimulation.