PARTICIPATION OF INTERFERON GAMMA IN THE LEUKOCYTE RECRUITMENT TO THE CENTRAL NERVOUS SYSTEM IN LPS INDUCED NEUROINFLAMMATION

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS SAIC - SAI - AAFE - NANOMED; 2021

Microglial cells are the main innate immune component of the central nervous system (They are similar to macrophages therefore, they express different innate immune receptors that make these cellscapable of producing pro inflammatory mediators, when they become activated in response to pathogens or injuriesPeripheral leucocytes are recruited to the CNS in response to cytokines and chemokines in the course ofneuroinflammatory processes and systemic infectionsDuring systemic inflammation, interferon γ (IFN γ) is induced and participates in the local inflammatory responsesobserved in different target organsThe aim of our work was to study the impact of IFN γ on the recruitment of peripheral leukocytes to the brain aftersystemic LPS injection