Artículos
Título:
Synthesis and characterization of binary and ternary complexes of diclofenac with a Methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Año: 2010 vol. 45 p. 4079 - 4079
Resumen:
ere, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and
methyl-b-cyclodextrin (M-b-CD) in the presence or absence of monoethanolamine (MEA). Several
techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was
increased by the addition of M-b-CD. However, the DCF solubility increase was more significant by the
addition of M-b-CD in the presence of MEA. In vitro permeation experiments through excised human skin
revealed that DCF was enhanced by M-b-CD. Nevertheless, further improvement in the flux and the
permeability coefficient of DCF was obtained by the ternary system DCF-M-ß-CD-MEA.