Exploring ZnO Nanoparticles in Antibiotic Therapy

MARIA JULIA MORA, IVANA ROMINA SCOLARI, ANDREA MAILEN ADAM AND GLADYS ESTER GRANERO

Determinations in Nanomedicine & Nanotechnology

Crimson Publishers

Lugar: New York; Año: 2022

oday, the raise in the rate of infectious diseases and the emergence of Multidrug-Resistant (MDR) bacteria has resulted in an increased number of associated hospital-acquired and community-acquired infections and mortality, so there is an urgent need to develop alternative antimicrobial strategies. For this purpose, zinc oxide nanoparticles (ZnO NPs) have demonstrated potent antibacterial activity and biocompatibility. In contrast to the conventional antibiotics, they are able to inhibit or interfere with bacterial Quorum Sensing (QS) and biofilm formation. Also, they are less sensitive to the development of resistance towards microorganisms. In addition, their zinc’s immunomodulatory effects contribute to the antimicrobial activity of conventional antibiotics. Moreover, there have been reported synergistic effects of ZnO NPs with various antibiotics. However, it is important to note that even though ZnO NPs have a wide range of antibacterial activities toward various microorganisms;