Development of Isoniazid Polymeric Nanoparticles for tuberculosis treatment

ANDREA M. ADAM; MARIA J. MORA; GLADYS E. GRANERO

Córdoba

Congreso; 6º Reunión Internacional de Ciencias Farmacéuticas (RICIFA); 2021

In recent decades, a large number of studies have focused on developing new efficient drug deliverysystems. Among them, formulations for pulmonary drug delivery biopolymer-based nanoparticles(NPs) appear to be the most promising due to their ability for controlled release and to target them to a specific site into the respiratory tract.Chitosan (CHI) is a cationic polysaccharide which has gained increasing interest to fabricate nanocarrier systems because it is biodegradable, biocompatible, non-toxic and has mucoadhesive properties.Isoniazid (IZN) is an antibiotic used for the treatment of tuberculosis.The aim of this work was to develop and characterize IZN loaded CHI NPs, as an antibiotic delivery system for tuberculosis treatment.CHI NPs, empty and loaded with IZN, were prepared by ionic gelation method, using sodiumtripolyphosphate (TPP) as cross-linked agent. NPs were characterized by determining their average size and surface charge potential by Dynamic Light Scattering.Empty and IZN loaded CHI NPs were synthesized in a molar ratio of 7:1. The size of empty and loaded NPs obtained were about 251nm and 241 nm, respectively, and the charge potential on the surface of NPs was ~ +18mV.In summary, CHI nanoparticles can be promising as inhalatory nanocarrier of anti-tuberculosisantibiotics.