Artículos
Título:
Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats.
Autor/es:
CARLINI VP, ; GHERSI M, ; GABACH L,; SCHIÖTH HB, ; PÉREZ MF, ; RAMIREZ OA, ; FIOL DE CUNEO M, ; DE BARIOGLIO SR.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2011 p. 145 - 145
Resumen:
13-amino acid peptide named neuronostatin (NST) encoded in the
somatostatin pro-hormone has been recently reported. It is produced
throughout the body, particularly in brain areas that have significant
actions over the metabolic and autonomic regulation. The present study
was performed in order to elucidate the functional role of NST on
memory, anxiety-like behavior and food intake and the hippocampal
participation in these effects. When the peptide was intra-hippocampally
administered at 3.0 nmol/μl, it impaired memory retention in both,
object recognition and step-down test. Also, this dose blocked the
hippocampal long-term potentiation (LTP) generation. When NST was
intra-hippocampally administered at 0.3 nmol/μl and 3.0 nmol/μl,
anxiolytic effects were observed. Also, the administration in the third
ventricle at the higher dose (3.0 nmol/μl) induced similar effects, and
both doses reduced food intake. The main result of the present st