Resumen:
n a previous paper we have demonstrated that the orexigenic peptide
Ghrelin (Ghr), increases memory retention in rats and mice. In the
present work we evaluated the Ghr effect when it was administered
previous the training session or previous the test session (24h after
training) on the memory performance, using step-down test. The results
showed that the intra-hippocampal Ghr administration previous the
training session improved the long-term memory in this task, but did not
modify the short-term memory. Nevertheless, when the Ghr was
administrated previous the test session, no changes were observed in the
memory performance. Taking into account these results and other
previously published by our group, we could hypothesizes that Ghr may
modulate specific molecular intermediates involved in memory
acquisition/consolidation but not in the retrieval.