Layered double hydroxide nanoparticles customization by polyelectrolyte adsorption: mechanism and effect on particle aggregation

VASTI, CECILIA; BORGIALLO, ANDRÉS; GIACOMELLI, CARLA E.; ROJAS, RICARDO

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

ELSEVIER SCIENCE BV

Año: 2017 vol. 533 p. 316 - 316

0927-7757

dsorption of polyelectrolytes (PEs) is a common strategy for stabilizing nanoparticles and customizing their properties. Although scarcely explored for layered double hydroxide nanoparticles (LDH-NPs), it can be used to increase their functionality in pharmaceutical and biomedical applications, among others. In this work, LDH-NPs intercalated with chloride, ibuprofen and ketoprofen were synthesized and modified with carboxylate containing PEs with different structures and physicochemical properties. The PEs adsorption mechanism on LDH-NPs and its effect on the aggregation of the obtained hybrids were studied by zeta potential and hydrodynamic diameter determinations on chloride intercalated LDH-NPs dispersions in the presence of polyacrylate (PA) at different concentrations. PA adsorption behavior was compared to that of citrate anion to contrast the adsorption mechanism of PEs and anions. Afterwards, the study was extended to other PEs (alginate and carbomer) as well as to drug inter