Magnetically controlled insertion of magnetic nanoparticles into membrane model

SARA NATALIA MOYA BETANCOURT; CANDELARIA I. CÁMARA; JUAREZ A. VALERIA; JULIETA S. RIVA

Biochimica et Biophysica Acta - Biomembranes

Elsevier B.V.

Año: 2024 vol. 1866 p. 1 - 1

olysaccharide–coated magnetic nanoparticles (MNPs) have been reported to show potential applications in many biomedical fields. In this report, we have studied the interactions between magnetite (Fe3O4) MNPs functionalized with polysaccharides (diethylamino–ethyl dextran, DEAE–D or chitosan, CHI) with different membranes models by Langmuir isotherms, incorporation experiments, and brewster angle microscopy (BAM). In this report, zwitterionic 1,2–distearoyl–sn–glycerol–3–phosphoethanolamine (DSPE) and anionic 1,2–distearoyl–sn–glycerol–3–phosphate (DSPA) phospholipid, were used to form membrane models. Incorporation experiments (π–t) as well as the compression isotherms demonstrate positive interactions between MNPs and DSPE or DSPA monolayers. The study assessed the impact of varying initial surface pressure on a preformed phospholipid monolayer to determine the maximum insertion pressure (MIP) and synergy. Our findings indicate that the primary driving force of the coated MNPs i