Novel Antibacterial Resin-Based Filling Material Containing Nanoparticles for the Potential One-Step Treatment of Caries

NATALIA ANGEL VILLEGAS;; M. JAZMIN SILVERO COMPAGNUCCI; MARTIN SAINZ AJÁ; DIAMELA MARÍA ROCCA; MARÍA CECILIA BECERRA,; GUSTAVO FABIÁN MOLINA; SANTIAGO DANIEL PALMA

Journal of Healthcare Engineering

Hindawi

Lugar: Londres; Año: 2019

2040-2295

he aim of this work was to study the application of resin filling containing nanomaterials for the potential treatment of caries. Zinc nanoparticles (ZnO@NP, 50 nm) were chosen for their antimicrobial capacity against aerobic bacteria, and here, they have proved to be bactericidal against anaerobic bacterial strains (Streptococcus mutans, Streptococcus mitis, and Lactobacillus spp.). Potential mechanism of action is proposed based on microbiological assays and seems to be independent of oxidative stress because the nanoparticles are effective in microaerophilic conditions. The loading of nanoparticles on the demineralized dental surface and their infiltration power were significantly improved when ZnO@NP were carried by the resin. Overall, this material seems to have a high potential to become a one-step treatment for caries lesions.