Design and development of reinforced antibiotic eye drops in a community pharmacy

QUINTEROS, DANIELA ALEJANDRA; VALLE BESSONE, CAROLINA DEL; RAMIREZ, MARÍA LAURA; MARTINEZ, SOFÍA MICKAELA; VILRRUBI, SILVINA MABEL; VILLEGAS, NATALIA ÁNGEL; ALLEMANDI, DANIEL ALBERTO

Pharmacy & Pharmacology International Journal

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Año: 2021 vol. 9 p. 242 - 242

bjective: Develop sterile vancomycin-amikacin reinforced antibiotics in smaller batches of finished products than those produced at the industrial level and under different working conditions. In this work, critical aspects concerning the elaboration process such as equipment and process evaluation, protocol development, physicochemical characterization, and microbiological tests were analyzed. In the first stage, the preparation of the formulations was carried out in the Department of Pharmaceutical Sciences of the Faculty of Chemical Sciences of the National University of Cordoba. In the second stage, the eye drops were prepared in the laboratory of Farmacia Vilarrubi, an office pharmacy authorized by the health authority and dedicated to the preparation of non-sterile compounding formulations. Both samples prepared at different manufacturing sites were subjected to the same physicochemical and microbiological tests.Methods and results: The sample compounding formulations of Vancomy