Antioxidant Role of Vitamin E in Atherogenesis induced by Hyperfibrinogenemia

LLORENS CANDELARIA; BAEZ MARÍA DEL CARMEN; TARÁN MARIANA; CAMPANA VILMA RENEÉ; FONSECA ISMAEL; OYOLA ELSA; PALMA JOSÉ; MOYA MÓNICA

REVISTA ARGENTINA DE CARDIOLOGÍA

SOCIEDAD ARGENTINA DE CARDIOLOGÍA

Lugar: Buenos Aires Argentina; Año: 2010 vol. 85 p. 405 - 405

0034-7000

ith the aim of studying the effect of vitamin E over oxidative stress due to hyperfibrinogenemia (HF) in an experimental model of atherogenesis and the possible normalization of oxidative stress markers; nitric oxide (NO), L-citrulline, superoxide dismutase (SOD) and involution of histopathologic lesions in the thoracic aorta were evaluated. The study was performed in 36 rats, Wistar strain, which were divided into three groups (n = 12 each): A, control; B, HF x 90 days; C, HF x 90 days + vitamin E. HF was induced by adrenaline injections (0.1 ml/day/rat) for 90 days. The dose of vitamin E was 2 mg/day/rat for 75 days. Fibrinogen levels (mg/dl), NO (uM) and L-citrulline (mM) were measured in plasma and SOD activity (U/ml) was measured in red blood cell lysate using spectrophotometry. Sections of thoracic aorta were analyzed using optical microscopy (OM). For the statistical analysis, MANOVA and Fisher?s exact test were used; a significant level of p < 0.05 was established. A significa