Oxidative stress and mitochondrial adaptive shift during pituitary tumoral growth

SABATINO, MARIA EUGENIA; GRONDONA, EZEQUIEL; SOSA, LILIANA D.V.; MONGI BRAGATO, BETHANIA; CARREÑO, LUCIA; JUAREZ, VIRGINIA; DA SILVA, RODRIGO A.; REMOR, ALINE; DE BORTOLI, LUCILA; DE PAULA MARTINS, ROBERTA; PÉREZ, PABLO A.; PETITI, JUAN PABLO; GUTIÉRREZ, SILVINA; TORRES, ALICIA I.; LATINI, ALEXANDRA; DE PAUL, ANA L.

FREE RADICAL BIOLOGY AND MEDICINE

ELSEVIER SCIENCE INC

Año: 2018 vol. 120 p. 41 - 41

0891-5849

he cellular transformation of normal functional cells to neoplastic ones implies alterations in the cellular metabolism and mitochondrial function in order to provide the bioenergetics and growth requirements for tumour growth progression. Currently, the mitochondrial physiology and dynamic shift during pituitary tumour development are not well understood. Pituitary tumours present endocrine neoplastic benign growth which, in previous reports, we had shown that in addition to increased proliferation, these tumours were also characterized by cellular senescence signs with no indication of apoptosis. Here, we show clear evidence of oxidative stress in pituitary cells, accompanied by bigger and round mitochondria during tumour development, associated with augmented biogenesis and an increased fusion process. An activation of the Nrf2 stress response pathway together with the attenuation of the oxidative damage signs occurring during tumour development were also observed which will probab