Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia

BRAIN BEHAVIOR AND IMMUNITY

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2022 vol. 101 p. 359 - 359

0889-1591

tressful experience-induced cocaine-related behaviors are associated with a significant impairment of gluta-matergic mechanisms in the Nucleus Accumbens core (NAcore). The hallmarks of disrupted glutamate homeo-stasis following restraint stress are the enduring imbalance of glutamate efflux after a cocaine stimulus andincreased basal concentrations of extracellular glutamate attributed to GLT-1 downregulation in the NAcore.Glutamate transmission is tightly linked to microglia functioning. However, the role of microglia in the biologicalbasis of stress-induced addictive behaviors is still unknown. By using minocycline, a potent inhibitor of microgliaactivation with anti-inflammatory properties, we determined whether microglia could aid chronic restraint stress(CRS)-induced glutamate homeostasis disruption in the NAcore, underpinning stress?induced cocaine self-administration. In this study, adult male rats were restrained for 2 h/day for