Cyclodextrin and Meglumine-based microemulsions as a poorly water-soluble drug delivery system

ALOISIO, C.; GOMES DE OLIVEIRA A.; LONGHI, M.R

JOURNAL OF PHARMACEUTICAL SCIENCES

JOHN WILEY & SONS INC

Lugar: New York; Año: 2015 vol. 105 p. 2703 - 2703

0022-3549

yclodextrins and meglumine are pharmaceutical excipients widely used to improve solubility of poorly water-soluble drugs. The purpose of this work was to study the effect of cyclodextrins (CD) or meglumine (MEG) on the internal microstructure of soya oil-based O/W microemulsions (ME) and on the modulation of the solubility and release rate of class II model hydrophobic drugs, sulfamerazine (SMR) and indomethacin (INM). The pseudoternary phase diagrams reveled that higher proportions of oil phase, as well as the presence of ß-cyclodextrin (ßCD), methyl ß-cyclodextrin and MEG favored the incorporation of the drugs. The conductivity studies, particle size and zeta potential analysis showed that the O/W ME structure remained unaffected and that the ME presented reduced droplet sizes after the incorporation of the ligands. The drug-component interactions were assessed by proton Nuclear Magnetic Resonance studies. The highest incorporations of SMR (35.6 mg/ml) and INM (73.1 mg/ml) were obta