Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine

ALOISIO C.; GOMES DE OLIVEIRA A.; LONGHI, M.R.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 100 p. 64 - 64

0731-7085

his study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with B-(BCD), methyl-(MBCD) and hydroxypropyl-B-cyclodextrin (HPBCD) using meglumine (MEG) as the ternary component. The combination of MEG with MßCD resulted the best approach, with an increased effect (29 fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MßCD or HPßCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MßCD or HPßCD in the ternary liofilized systems. The ternary complexes with ßCD and MßCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility a