Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol.

ALOISIO C.; BUENO, MS.; PONCE PONTE, M.; PAREDES, A.; PALMA, S.; LONGHI, M.

Therapeutic Delivery

Future Medicine Ltd.

Año: 2019 vol. 10 p. 624 - 624

2041-5990

he aim of this work was to develop solid self-emulsifying drug delivery systems (SEDDS), using the spray drying technique, for the oral delivery of Resveratrol (RES). The SEDDS were obtained from lipid-based formulations containing cod liver oil as oil phase, and phosphate buffer solution of pH 7.4 as aqueous phase. Three formulations with a different surfactant system composition were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE 40 (EU)/Sodium Oleate (SO) (system A); FCS/Tween®80 (TW) /SO (system B) and FCS/EU/TW (system C). From pseudoternary phase diagrams, a wide range of combinations was observed to obtain transparent systems. It was possible to incorporate a high concentration of RES in the formulations, observing the greatest incorporation when using system C (21.26 mg/mL). Besides, lactose, maltodextrin, colloidal silicon dioxide (CSD) and CSD: sodium croscarmelose (SC) mixtures were evaluated as adsorbent materials for the spray drying process. Solid SEDDS with the hig