Study and development of microemulsion formulations to increase the permeability of acyclovir

PONCE PONTE, MICAELA; BIANCO, MARTINA; LONGHI, MARCELA; ALOISIO, CAROLINA

JOURNAL OF MOLECULAR LIQUIDS

ELSEVIER SCIENCE BV

Año: 2022 vol. 348

0167-7322

he purpose of this study was to improve the permeability of acyclovir (ACV) by developing a water-in-oil microemulsion, since it is an important factor that influences the oral absorption and, consequently, the oral bioavailability of drugs. Pseudoternary phase diagrams (PTPD) were constructed to identify the regions for obtaining microemulsions (ME). From the region of fluid transparent systems, five ME were chosen to evaluate the effect on ACV permeability by using twocompartment horizontal Franz diffusion cells, using a bio-mimetic artificial membrane, which simulates the typical lipophilic characteristics of the biological membranes. The characterization of ME was carried out by PTPD, conductivity determination and Nuclear Magnetic Resonance studies.The formulation that showed the higher incorporation of ACV (81.57 mg/ml) consisted of 13.3% Polysorbate 80, 13.3% ethanol, 6.6% ginger oil and 66% water. An increase in ACV permeability was observed, reaching an apparent permeability