THE THYROID HORMONE TRIIODOTHYRONINE REINVIGORATES DENDRITIC CELLS AND POTENTIATES ANTI-TUMOR IMMUNITY

ALAMINO VA; MONTESINOS MM; RABINOVICH GA; PELLIZAS CG

OncoImmunology

Taylor & Francis

Lugar: Oxfordshire; Año: 2016 vol. 5 p. 1 - 1

endritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.