Los niveles séricos de Interleucina 22 e Interleucina 6 disminuyen luego del tratamiento en pacientes con artritis reumatoidea

CLARA ALVAREZ FERREIRA; ALAMINO VANINA ALEJANDRA; CRISTINA ACOSTA; LAURA ONETTI; EDUARDO MUSSANO; CADILE IGNACIO; ZACCA ESTEFANÍA; ADRIANA GRUPPI; ACOSTA RODRÍGUEZ EVA; FERRERO PAOLA

Revista argentina de reumatología

Sello Editorial Lugones

Año: 2020

0327-4411

troduction: Rheumatoid arthritis is characterized by synovium inflammation due to the infiltration of immune cells that secrete Th17 cytokines like IL-22 and IL-6. The dynamics of these cytokines during the treatment remain unknown. The aim of this study was to evaluate the levels of IL-22 and IL-6 serum and synovial fluid (SF) in correlation with different biochemical and clinical parameters and treatment-associated changes.Material and methods: Seventy-seven RA patients and 30 controls were recruited. Thirty patients were evaluated after 3 months of treatment and SF was collected of 12 patients. ESR, CRP, RF, anti-CCP hs, IL-22 e IL-6 were measured. DAS28 was used to assess disease activity and response to treatment followed EULAR criteria.Results: There were not differences in serum IL-22 and IL-6 levels between patients and controls. Cytokine levels decreased after treatment, mainly in responder patients. IL-22 was decreased and IL-6 was increased in SF compared to serum. IL-6 cor