Aggregation study of Triarylmethane dyes

HANIEWICZ, CINTHIA; VARA, JIMENA; ORTIZ, CRISTINA

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH

Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India

Año: 2014

hotodynamic therapy (PDT) is a non-invasive medical technology that involves three key components: photosensitizer (PS), light and tissue oxygen to generate reactive oxygen species, which cause cells death. Numerous studies in bibliography report that many PS tend to aggregate in aqueous solution. Due to these molecular assemblies present lower photochemical reactivity than the respective monomer, selfaggregation of New Fuchsin (NF) and its di-iodinated derivative (NFI2) were evaluated by UV-Visible Spectroscopy. Dye concentration effect in N,N-Dimethylformamide (DMF), DMF: water mixtures and aqueous solution were compared. UV-Visible spectra obtained for NFI2 in DMF showed a unique band with a maximum absorption at 460 nm. When water proportion was increased, a new band at 574 nm was observed and the dye presented maxima absorption at 558 nm and 525 nm in pure aqueous media. Moreover, absorption spectra of NF in DMF showed a single band with a maximum absorbance at 558 nm, while in a