Natural anthraquinones as novel photosentizers for antiparasitic photodynamic inactivation

JESICA A DIMMER; FERNANDA V. CABRAL; CAETANO P. SABINO; CAMILA RAMOS SILVA; SUSANA C. NÚÑEZ MONTOYA; JOSÉ LUIS CABRERA; MARTHA SIMOES RIBEIRO

PHYTOMEDICINE

ELSEVIER GMBH

Año: 2019 vol. 61

0944-7113

ackground: Cutaneous leishmaniasis (CL) is a vector-borne disease caused by obligate protist parasites from the genus Leishmania. The potential toxicity as well as the increased resistance of standard treatments has encouraged the development of new therapeutical strategies. Photodynamic inactivation (PDI) combines the use of a photosensitizer and light to generate reactive oxygen species and kill cells, including microorganisms. Vegetal kingdom constitutes an important source of bioactive compounds that deserve to be investigated in the search of naturally occurring drugs with leishmanicidal activity.Purpose: The purpose of this study was to test the antiparasitic activity of PDI (ApPDI) of five natural anthraquinones (AQs) obtained from Heterophyllaea lycioides (Rusby) Sandwith (Rubiacae). To support our results, effect of AQ mediated-PDI on parasite´s morphology and AQ uptake were studied. Cytotoxicity on fibroblasts was also evaluated.Study design/Methods: Two monomers, soranjidio