Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

MARCHESE, N.A.; ARTUR DE LA VILLARMOIS, E.; BASMADJIAN, O.M.; PEREZ. M.F.; BAIARDI, G.; BREGONZIO, C.

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2016

0033-3158

ationale. Angiotensin II, by activation of its brain AT1-receptors, plays an active role as neuromodulator in dopaminergic transmission. These receptors participate in the development of Amphetamine-induced behavioral and dopamine release sensitization. Dopamine is involved in cognitive processes and provides connectivity between brain areas related to these processes. Amphetamine by its mimetic activity over dopamine neurotransmission, elicits differential responses after acute administration or after re-exposure following long-term withdrawal periods in different cognitive processes.Objective. To evaluate the AT1-receptors involvement in the acute and long-term Amphetamine-induced alterations in long-term memory and in cellular related events.Methods. Male Wistar rats (250-300g). Acute effects: Amphetamine (0.5/2.5 mg/kg i.p.) was administered after post-training in the inhibitory-avoidance (IA) response. The AT1-receptor blocker Losartan was administered i.c.v. before a single dose