Brain angiotensin II involvement in chronic mental disorders

BASMADJIAN, OSVALDO MARTIN; OCCHIEPPO, VICTORIA BELÉN; MARCHESE, NATALIA ANDREA; BAIARDI, GUSTAVO; BREGONZIO, CLAUDIA

PROTEIN AND PEPTIDE LETTERS

BENTHAM SCIENCE PUBL LTD

Año: 2017 vol. 24 p. 817 - 817

0929-8665

ackground: The functioning of the central nervous system is complex and it implies tight and coordinated interactions among multiple components. Neurotransmitters systems imbalance is a hallmark in the central nervous system (CNS) disorders. These pathologies profoundly impact the social, cultural, and economic perspective worldwide. The etiopathology of CNS illnesses is still poorly understood, making their treatment difficult. Brain angiotensin II (Ang II), through its AT 1 receptors, modulates dopaminergic, glutamatergic and GABAergic neurotransmission, which are responsible for movement control, cognition, emotions and stress responses. Alterations of these functions, concomitant with modified brain reninangiotensin system (RAS) components, have been described in CNS pathologies like depression, Parkinson, Alzheimer, and schizophrenia. In this sense, altered functionality of angiotensin I converting enzyme and AT 1 receptors, is associated with augmented susceptibility to the occu