EARLY PROTEIN MALNUTRITION ATTENUATES THE ANTIDEPRESSANT-LIKE EFFECT OF DMI IN THE FORCED-SWIM TEST IN ADULTS RATS MATERNALLY SEPARATED

GUTIERREZ, MC; NASI MEDEOT, L; PERONDI, MC; CUADRA, GR; VALDOMERO, A

Mar del Plata

Congreso; SAIC-SAI-SAFE; 2016

SAFE

Previous results demonstrate that perinatal protein malnutritionfacilitates depressiveliMe behaviors in rats that have experiencedmaternal separation. Thus, undernutrition significantly increasesthe immobility time in the forced sYim test FST. Consideringthe long-lasting alterations produced in the central monoaminergicsystems, as a consequence of nutritional insult, Ye study the treatmenteffects of desipramine &/+ a highly selective reuptaMeinhibitor of norepinephrine on the behavioral changes found in theFST. To this aim, different groups of adult control C and proteindeprived rats & maternally separated daily for min from 20& until 20& /Sgroup Yere treated Yith &/+ mg/Mg/day,+2 or saline during days. Total immobility time Yas measuredfor min period in the FST and compared Yith rats that Yere notsubmitted to maternal separation (NMS). Although DMI treatmentproduced an antidepressantliMe effect in both C 0/S and /S and& 0/S and /S groups, rats in &/S group shoYed a significanthigher immobility time in the forcedsYim test. These preliminaryresults indicate that early nutritional insult alter the pharmacologicalreactivity to &/+, highlighting an incapacity to induce neuroadaptativechanges incentral pathYays involved in &/+ mechanism ofaction. +ndeed, they suggest the possibility of an altered reactivity totherapeutic treatments in adult subjects malnourished at early life.