Self-organized drug-interpolyelectrolyte nanocomplexes loaded with anionic drugs. Characterization and in vitro release evaluation

PALENA, MARÍA CELESTE; GARCÍA, MÓNICA CRISTINA; MANZO, RUBÉN HILARIO ; JIMENEZ-KAIRUZ, ALVARO F.

EDITIONS SANTE

Lugar: Lille; Año: 2015 vol. 30 p. 45 - 45

he current study is focused on physicochemical characterization and in vitro drug delivery evaluation of self-organized nanoparticles based on drug-interpolyelectrolyte complexes (DIPEC). The interaction between two oppositely charged polymethacrylates, Eudragit® EPO and L100, and four non-steroidalanti-inflammatory drugs, Salicylic Acid, Benzoic Acid, Ketoprofen and Naproxen was studied. DIPEC nanoparticles produce translucent and stable aqueous dispersions where a remarkably high proportion of drug (between 57 and 95%) is condensed with polyelectrolyte (PE) under the form of ionic pairs. They exhibited particle size in the range of 120e198 nm and high positive zeta potential, contributing to physical stability. The sign of zeta potential shifted from positive to negative by changes in composition of DIPEC. Thermal analysis and X-ray diffraction patterns of freeze dried DIPEC showed the amorphous state of products and the complete interaction of PE and drug. Solid complexes we