Structural and morphological aspects of (fluoro)quinolone delivery by layered double hydroxide nanoparticles

SALGUERO, YADIRA; GARCÍA, MÓNICA CRISTINA; MOSCONI, GIULIANA; ROJAS, RICARDO

NEW JOURNAL OF CHEMISTRY

ROYAL SOC CHEMISTRY

Año: 2018 vol. 42 p. 19144 - 19144

1144-0546

ayered double hydroxides (LDHs) have been proposed as delivery systems (DSs) of (fluoro)quinolones (QLNs) to overcome their low bioavailability and to prevent the emergence of resistant bacteria. Both LDH-DS synthesis as nanoparticles (NPs) and QLN interactions with the metal ions that constitute the layers are essential to improve their physicochemical, biopharmaceutical and antimicrobial properties. Here, LDH-DSs containing the basic form of nalidixic acid (Nal), used as a probe, were obtained by coprecipitation at variable and constant pH (LDH-Nal-pHvar and LDH-Nal-pHcte, respectively). For both syntheses, LDH NPs containing Nal anions (LDH-Nal-NPs), with sizes between 30 and 40 nm, were obtained. A coordination compound (Mg(Nal)2·4H2O, Mg(Nal)2) was also concurrent for LDH-Nal-pHcte, which modulated the drug release profile and antimicrobial properties of the LDH-Nal-NPs. Thus, Nal release from LDH-Nal-pHvar was produced mainly by anion exchange. The best fits, obtained for the Hi