Drug-containing layered double hydroxide/alginate dispersions for tissue engineering

ZANIN, JUAN PABLO; GIL, GERMAN; GARCÍA, MÓNICA C; ROJAS, RICARDO

ChemEngineering

MDPI AG

Año: 2022

lginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissueengineering because of its easy gelation and biocompatibility, and the incorporation of drugs intoits formulation allows for its functionality to be extended. However, Alg presents a low celladhesion and proliferation capacity, and the incorporation of drugs may further reduce itsbiocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials,as they increase cell adhesion and interaction and provide drug storage and controlled release. Inthis work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constantpH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored.Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm theirpotential as biomaterials for tissue engineering. T