Promising tamoxifen-loaded biocompatible hybrid magnetic nanoplatforms against breast cancer cells: synthesis, characterization and biological evaluation

CADENA CASTRO, DIEGO; GATTI, GERARDO; MARTÍN, SANDRA E.; UBERMAN, PAULA M.; GARCÍA, MÓNICA C.*

NEW JOURNAL OF CHEMISTRY

ROYAL SOC CHEMISTRY

Año: 2021 vol. 45 p. 4032 - 4032

1144-0546

ron oxide nanoparticles are promising nanosystems for designing drug delivery platforms owning to their excellent biocompatibility and unique magnetic properties. Herein, we report for the first time a simple and environmentally friendly methodology for obtaining stable hybrid magnetic nanoplatforms (HMNP) as nanocarriers for tamoxifen (TMX). Thus, Fe3O4nanoparticles were conjugated withl-cysteine (l-Cys) and/or hyaluronic acid (HA). Two superparamagnetic nanoplatforms, Fe3O4-l-Cys-HA and Fe3O4-HA (11 and 14 nm, respectively), were prepared. Their physicochemical and pharmaceutical properties, biocompatibility and cytotoxic effect against MCF-7 breast cancer cells were evaluated. The incorporation ofl-Cys into the Fe3O4-l-Cys-HA HMNP effectively improved their aqueous dispersibility and colloidal stability (up to 8 h). Both HMNP exhibited high TMX loading efficiency (>60%), hydrophilic behavior and magnetic response. TMX was released in a sustained manner and release kinetic data indi