Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration

FORMICA, MARÍA LINA; AWDE ALFONSO, HAMOUDI GHASSAN; PAREDES, ALEJANDRO JAVIER; MELIAN, MARÍA ELISA; CAMACHO, NAHUEL MATÍAS; FACCIO, RICARDO; TÁRTARA, LUIS IGNACIO; PALMA, SANTIAGO DANIEL

Pharmaceutics

MDPI

Lugar: Basel; Año: 2023 vol. 15 p. 1 - 1

riamcinolone acetonide (TA) is a powerful anti-inflammatory drug used in the treatment of inflammatory ocular disorders; however, its poor aqueous solubility and ocular anatomical barriers hinder optimal treatment. The aim of this work was to obtain triamcinolone acetonide nanocrystals (TA-NC) to improve ocular corticosteroid therapy. Self-dispersible TA-NC were prepared by the bead milling technique followed by spray-drying, exhaustively characterized and then evaluated in vivo in an ocular model of endotoxin-induced uveitis (EIU). Self-dispersible TA-NC presented an average particle size of 257 ± 30 nm, a narrow size distribution and a zeta potential of −25 ± 3 mV, which remained unchanged for 120 days under storage conditions at 25 °C. In addition, SEM studies of the TA-NC showed uniform and spherical morphology, and FTIR and XRDP analyses indicated no apparent chemical and crystallinity changes. The subconjunctival administration of TA-NC in albino male white rabbits showed