IL-17–Mediated Immunity Controls Skin Infection and T Helper 1 Response during Experimental Microsporum canis Dermatophytosis

BURSTEIN, VERÓNICA L.; GUASCONI, LORENA; BECCACECE, IGNACIO; THEUMER, MARTIN G.; MENA, CRISTIAN; PRINZ, IMMO; CERVI, LAURA; HERRERO, MÓNICA; MASIH, DIANA T.; CHIAPELLO, LAURA S.

JOURNAL OF INVESTIGATIVE DERMATOLOGY

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2018 vol. 138 p. 1744 - 1744

0022-202X

espite worldwide prevalence of superficial mycoses, the immune response in dermatophytosis has scarcely been investigated. In this study, we developed a model of superficial skin infection in C57BL/6 mice with Microsporum canis, a highly prevalent human pathogen. This model mimics mild inflammatory human dermatophytosis, characterized by neutrophil recruitment and fungal invasion limited to the epidermis and exhibits the establishment of a specific T helper type 17 immune response during infection. By using IL-17RA? or IL-17A/F?deficient mice we showed that, in the absence of a functional IL-17 pathway, M. canis extensively colonizes the epidermis and promotes an exaggerated skin inflammation and a shift to an IFN-γ?mediated (T helper type 1) response. IL-17 signaling was not involved in neutrophil influx to skin or fungal invasion to deeper tissues. Finally, this study shows that skin langerin-expressing cells contribute to the antifungal T helper type 17 response in vivo. In co