Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

MICAELA A. MACCHIONE; CARLOS GUERRERO-BELTRÁN; ANABELLA P. ROSSO; ESTEBAN EUTI; MARISA MARTINELLI; MIRIAM STRUMIA; MARÍA ÁNGELES MUÑOZ-FERNÁNDEZ

Scientific Reports

Nature Publishing Group

Año: 2019

2045-2322

timuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly (N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly (N-vinylcaprolactam) nanogels against the HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent show antiviral behavior against the HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.