Anti-GM1 IgG antibodies in Guillain-Barre syndrome: fine specificity is associated with disease severity

LARDONE R.; YUKI N.; ODAKA M.; DANIOTTI J.L.; IRAZOQUI F.; NORES G.

B M J PUBLISHING GROUP

Año: 2010 vol. 81 p. 629 - 629

Background Clinical severity of GuillaineBarre´ syndrome(GBS) is highly variable, but the immunopathologicalreason is unknown.Objective The study was designed to show whichantibody parameters are associated with diseaseseverity in GBS patients with serum anti-GM1 IgGantibodies.Methods Thirty-four GBS patients with anti-GM1 IgGantibodies were grouped into two categories according todisease severity at nadir: mild (grades 1e3 by Hughesfunctional scale, n¼13) and severe (grades 4 and 5,n¼21). Titre, affinity, fine specificity and cell binding ofanti-GM1 antibodies were obtained and comparedbetween the two groups.Results No differences in antibody titre (GM1-ELISA) oraffinity were found between the two patient groups. Incontrast, the severe group showed a significantly higherfrequency (95%, vs 46% in the mild group, p¼0.002) ofspecific (not cross-reacting with GD1b) anti-GM1