Dendritic cells and parasites: from recognition and activation to immune response instruction

CRISTINA MOTRÁN; LAURA AMBROSIO; XIMENA VOLPINI; DAIANA CELIAS; LAURA CERVI

SEMINARS IN IMMUNOPATHOLOGY

SPRINGER

Lugar: Berlin; Año: 2016

1863-2297

he effective defense against parasite infections requires the ability to mount anappropriate and controlled specific immune response able to eradicate the invadingpathogen while limiting the collateral damage to self-tissues. Dendritic cells are keyelements for the development of immunity against parasites; they control theresponses required to eliminate these pathogens while maintaining host homeostasis.Ligation of dendritic cells Pattern Recognition Receptors by Pathogen AssociatedMolecular Pattern present in the parasites initiates signaling pathways that lead to theproduction of surface and secreted proteins that are required, together with theantigen, to induce an appropriate, and timely regulated immune response. There isevidence showing that parasites can influence and regulate dendritic cell functions inorder to promote a more permissive environment for their survival. In this review, wewill focus on new insights about the ability of protozoan and helminth parasites or theirpr