Frequency, virulence factors and antifungal susceptibility of Candida parapsilosis species complex isolated from patients with candidemia in the central region of Argentina

VIGEZZI, CECILIA; ICELY, PAULA ALEJANDRA; DUDIUK, CATIANA; RODRIGUEZ, EMILSE; MIRÓ, MARÍA SOLEDAD; CASTILLO, GRACIELA; AZCURRA, ANA ISABEL; ABIEGA, CLAUDIO; CAEIRO, JUAN PABLO; RIERA, FERNANDO OSCAR; GARCÍA EFFRON, GUILERMO; SOTOMAYOR, CLAUDIA ELENA

JOURNAL DE MYCOLOGIE MEDICALE

MASSON EDITEUR

Lugar: Paris; Año: 2019

1156-5233

urposeOur objectives were to report species distribution and survival of patients with candidemia in Argentina´s central region and to establish the prevalence of C.parapsilosis sensu lato species, their virulence factors and their antifungal susceptibility profiles.MethodsYeasts isolated from bloodstream infections in Córdoba (Argentina) (n = 35) were molecularly identified. The production of lipase and acid aspartic protease (Sap), the adhesion capacity, and the isolates? ability to form biofilm were evaluated. The in vitro activity of 7 antifungal drugs was evaluated (CLSIdocument M27-4thed).ResultsC. albicans was the most prevalent species (48.57%) followed by C. parapsilosis sensu lato (28.57%). The 30-day survival rate for C. albicans candidemia was slightly lower than non-albicans blood infections (50.00% vs. 57.90%). C. parapsilosis sensu stricto and C. orthopsilosis account for 60% and 40% of the cryptic species. Sap production and biofilm formation capacity were higher in C.