Dectin-1 pathway-mediated immunomodulation in the local response during Candida albicans brain infection

VIGEZZI, CECILIA; RODRIGUEZ, EMILSE; MIRÓ, MARÍA SOLEDAD; ICELY, PAULA ALEJANDRA; CEJAS, HUGO; SOTOMAYOR, CLAUDIA ELENA

Congreso; LXV Annual Meeting of Sociedad Argentina de Inmunología; 2017

β-glucans recognition by Dectin-1 receptor is essential forantifungal response to opportunist C.albicans in the periphery,but in Central Nervous the results are controversial. b-glucansare widely recognized as immunomodulators, and it has beendemonstrated in vitro that the activation of microglia throughDectin-1 attenuates the production of proinflammatorycytokines.