The memory consolidation impairment induced by Interleukin-1β could be associated to changes in hippocampal structural plasticity

HERRERA GUADALUPE.; CALFA GASTON ; MACHADO IVANA.; LASAGA MERCEDES; SCIMONELLI TERESA.

Buenos Aires

Congreso; Second FALAN Congress. XXXI Annual Congress of the Argentinean Society for Research in Neuroscience.; 2016

Federation of Latin American and Caribbean Neuroscience Societies y Sociedad Argentina de Investigacion en Neurociencia

Pro-inflammatory cytokines can affect cognitive processes, such aslearning and memory. Accordingly, high levels of interleukin-1beta (IL-1b)in the brain could impair memory and also cytokines participated indetrimental changes in cognitive functions observed duringneurodegenerative diseases. Particularly, IL-1b influences theconsolidation and reconsolidation of hippocampus-dependent memories.We previously reported that administration of IL-1b in dorsal hippocampus(DH) impaired contextual fear memory consolidation. We also showedthat IL-1b administration produced a decrease in glutamate release fromDH synaptosomes and decreased brain-derived neurotrophic factor(BDNF) expression after contextual fear conditioning. Considering thatBDNF plays an important role in synaptic plasticity, in this study weevaluated if IL-1b could induce changes in hippocampal structuralplasticity. Preliminary results show that the impairment of contextual fearmemory following the IL-1b treatment was associated with a decrement inspine density in the DH, particularly in the mature dendritic spines(mushroom and stubby) without changes in immature dendritic spines(thin). Our data suggests that neuroinflammation interferes withexperience-dependent structural plasticity in DH.