The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae

KADIOGLU A; ECHENIQUE J; MANCO S; TROMBE MC; ANDREW P

AMER SOC MICROBIOLOGY

Año: 2003 vol. 71 p. 6676 - 6676

b> In Streptococcus pneumoniae, the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the micB::km