Competence modulation by the NADH oxidase of S. pneumoniae involves signal transduction

ECHENIQUE J; TROMBE MC

AMER SOC MICROBIOLOGY

Año: 2001 vol. 183 p. 768 - 768

b> Oxygen controls competence development in Streptococcus pneumoniae. Oxygen signaling involves the twocomponent signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB. We found that NADH oxidase (Nox) was required for optimal competence. Transcriptional analysis and genetic dissection showed that Nox was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of