Improving Properties of Albendazole Desmotropes by Supramolecular Systems with Maltodextrin and Glutamic Acid

BONGIOANNI, AGUSTINA; ARAÚJO, BRUNO SOUSA; DE OLIVEIRA, YARA SANTIAGO; LONGHI, MARCELA R.; AYALA, ALEJANDRO; GARNERO, CLAUDIA

AAPS PHARMSCITECH

SPRINGER

Lugar: Arlington; Año: 2018 p. 1 - 1

1530-9932

lbendazole, an effective broad-spectrum anthelmintic agent, showed unpredictable therapeutic response caused by poor water solubility and slow dissolution rate. Then, novel binary and multicomponent supramolecular systems of two different solid forms of albendazole (I and II) with maltodextrin alone or with glutamic acid were studied as an alternative to improve the oral bioavailability of albendazole. The interactions and effects on the properties of albendazole were studied in solution and solid state. The solid systems were characterized using Raman and Fourier transform-infrared spectroscopy, thermal analysis, powder X-ray diffraction, and scanning electron microscopy. The solubility measurements, performed in aqueous and simulated gastric fluid, showed that albendazole (form II) was the most soluble form, while its supramolecular systems showed the highest solubility in simulated gastric fluid. On the other hand, the dissolution profiles of binary and multicomponent systems in si