Study of the Interaction of 5-(alkylthio)-3H-1,2-dithiole-3-thiones with ß-Cyclodextrin.

MARTÍN E. ZOLOFF MICHOFF; ALEJANDRO M. GRANADOS; RITA H. DE ROSSI

Arkivoc

ARKAT

Año: 2005 p. 47 - 47

1424-6376

b> Abstract Dithiolthiones are a family of compounds which have a great current interest for their properties especially as anti carcinogens. The problem for the use of this type of compounds is that they are quite water insoluble and this represents a problem for their bioavalability. We have studied the interaction of 5-RS-3H-1,2-dithiole-3-thiones (R= ethyl, butyl, hexyl and octyl) with cyclodextrins and we report here that the ethyl and butyl derivatives form inclusion complexes with â-cyclodextrin with 1:1 stoichiometry. The complexes are characterized by Uv-vis, circular dichroism spectroscopy and by DSC analysis of the solid complexes. The solubility of the butyl derivative in water increases about two times in a solution of