Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ΔFosB expression in adult rats.

MARÍA C. PERONDI; MARÍA C. GUTIERREZ; ANALÍA VALDOMERO; GABRIEL R. CUADRA

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017

0166-4328

revious studies have indicated that neural changes induced by early nutritional insult cause an altered responseto pharmacological treatments, including addictive drugs. This study evaluates the influence of perinatal proteinmalnutrition in developing cross-sensitization to cocaine-induced rewarding effects in animals pre-exposed tomorphine.Different groups of well-nourished (C-rats) and protein-deprived animals (D-rats) were treated twice a day forthree days with increasing doses of morphine or with saline. After 3 days, the incentive motivational effects ofcocaine were assessed in a Conditioned Place Preference paradigm in both groups. In saline pre-treated animals,dose-response curves to cocaine revealed a conditioning effect in D-rats at doses of 5, 7.5 and 10 mg/kg, whilethis effect was observed in C-rats only with 10 and 15 mg/kg. Furthermore, when animals of both groups werepre-treated with escalating doses of morphine, cross-sensitization to the conditioning effect of cocaine