Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5 years

BRUNOTTO, M.; ZARATE, A. M.; BONO, A.; BARRA, J. L.; BERRA, S.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 50 p. 178 - 178

he aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 8540 patients with HNC and 9844 controls from 19 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. A meta-analysis was done on the studies that applied fixed and random models. People have an increase of polymorphism expression related to inflammation (NFKB1-294-ATTG, TNFa308-A2A2/A2A1, and TNFb252- B2B2/B2B1) or carcinogenic metabolism (GSTM1 null, and CYP1A1 m1/m1), representative of malignancy development. Furthermore, the increased expression of genes associated with the stabilization and repair of the cellular (OGG1-Asp267Asn, Ser279Gly Ile253Phe, 1578A > T, 1582C > T A