DNA repair, NFKβ, and TP53 polymorphisms associated with potentially malignant disorders and oral squamous cell carcinoma in Argentine patients

GALÍNDEZ, MARÍA FERNANDA; CARRICA, ANDRÉS; ZARATE, ANA MARÍA; SECCHI, DANTE; DON, JULIETA; BARRA, JOSÉ LUIS; BRUNOTTO, MABEL

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Mosby Inc.

Año: 2021 vol. 131 p. 339 - 339

2212-4403

bjective: An important strategy in cancer prevention is to identify individual susceptibilities for cancer development through the genomic profile. Developing countries such as Argentina have no data on genetic composition. The aim of this study was to evaluate the single nucleotide polymorphisms of genes related to DNA repair (XCCR3, XPD), cell cycle arrest/apoptosis (TP53), and inflammation (NFKβ) of patients with precancer and oral cancer and to contribute to recognizing potential risk of developing these pathologies, and incorporate the risk patients into a clinical follow-up program in Córdoba, Argentina. Study Design: A cross-sectional study was performed on 140 patients with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMDs), and controls. Genotyping of single nucleotide polymorphisms was performed using allele-specific polymerase chain reaction or restriction fragment length polymorphism techniques. The variables were evaluated by bivariate