The tumor suppressor gene presents a common polymorphism at

codon 72, encoding proline or arginine. These variants could modify

biological functions and are related to geographic latitude.

Purpose: Our purpose was to evaluate the prevalence and possible

relationship to both alleles with oral carcinoma (Ca), oral potentially

relationship to both alleles with oral carcinoma (Ca), oral potentially

malignant disorders (OPMD) or other stomatological (Con) lesions in

adult patients.

Material and methods: Cross-sectional study was designed, the 43

patients, both genders, aged 36?80 years were recruited at Dentistry

patients, both genders, aged 36?80 years were recruited at Dentistry

Faculty of Cordoba, Universidad Nacional de Córdoba?Argentina. The

detection of polymorphism at codon 72 was performed with the

allele specific PCR.

Results: We observed 33% of OPMD, 28% of Ca and 39% of Con; and

the male was presented higher percentage of Ca (35%) in relation to

the male was presented higher percentage of Ca (35%) in relation to

female with Ca (25%), however the inverse relationship was

observed with patients diagnosed with OPMD. The homozygous or

heterozygous status are high significant (p = 0.000) associated with

study lesions. The only patients with Ca (36%) and OPMD (30%)

study lesions. The only patients with Ca (36%) and OPMD (30%)

lesions are presented heterozygous status. And the presence of R72

allele was higher in Con patients (80%).

Conclusions: therefore, evidence of association among homozygosity/

heterozygosity for p53 arginine or proline and premalignant and

heterozygosity for p53 arginine or proline and premalignant and

malignant lesions in our population sample. It is known that the

accumulated number of variants on the same chromosome could

be additive or multiplicative for changes in function of p53 gene

and leading to increase the malignity risk.