Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid beta Peptide.

CHEN, K.; IRIBARREN P; HU, J.; CHEN, J.; GONG, W.; CHO, E.; LOCKETT, S.; DUNLOP, N. M.; WANG, J. M.

JOURNAL OF BIOLOGICAL CHEMISTRY

Año: 2006 vol. 281 p. 3651 - 3651

0021-9258

p style="margin: 0cm 0cm 0pt;" class="MsoNormal">The human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse homologue mFPR2 mediate the chemotactic activity of a variety of polypeptides associated with inflammation and bacterial infection, including the 42-amino acid form of amyloid b peptide (Ab42), a pathogenic factor in Alzheimer disease. Because mFPR2 was inducible in mouse microglial cells by proinflammatory stimulants, such as bacterial lipopolysaccharide, a ligand for the Toll-like receptor 4 (TLR4)