The role of formyl peptide receptor like 1 (FPR1/FPR2) in mononuclear phagocyte responses in Alzheimer?s disease.

IRIBARREN P; ZHOU, Y.; HU, J.; LE, Y.; WANG, J. M.

IMMUNOLOGIC RESEARCH

Año: 2005 vol. 31 p. 165 - 165

0257-277X

p class="abstract">Alzheimer disease (AD) is the most common neurodegenerative disease, affecting approx 4 million people in the United States in the year 2000 alone. Amyloid beta (Abeta) deposition, activated glial cells, and neuritic degeneration are the characteristic features of AD. Although the precise cause of AD has yet to be determined, a bulk of evidence suggests that inflammatory responses elicited by elevated Abeta peptides play an important role in the pathogenic process of the disease. In AD brain, mononuclear phagocytes (microglia) accumulate at the sites of Abeta peptide deposition. In vitro, Abeta peptides activate mononuclear phagocytes to release neurotoxic mediators. A number of cell-surface molecules have been reported to act as putative receptors for Abeta peptides, among which the G protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse homolog FPR2 have been shown to be expressed by activated microglial cells and mediate the chemotactic activity of